Procedures & Gynaecology
Amniocentesis & CVS
Diagnostic procedures to definitively test for chromosomal and genetic conditions in the baby.
What is Amniocentesis & CVS?
Amniocentesis and chorionic villus sampling (CVS) are invasive diagnostic procedures used to obtain fetal cells for chromosomal and genetic analysis. CVS is performed between 11 and 14 weeks by sampling placental tissue. Amniocentesis is typically performed after 15 weeks by sampling amniotic fluid. Both provide definitive genetic information about the baby, unlike screening tests which only estimate risk.
Why is it a Concern?
These procedures carry a small risk of miscarriage (approximately 0.1–0.5%). They are offered when the clinical benefit of a definitive diagnosis outweighs this small procedural risk — typically when screening has identified an elevated risk or when a specific genetic condition needs to be tested for.
Signs & Symptoms
- High-risk screening result (NIPT, combined screening, or ultrasound findings)
- Previous pregnancy affected by a chromosomal or genetic condition
- Known parental carrier status for a genetic condition
- Ultrasound findings suggesting a chromosomal abnormality
- Parental request for definitive prenatal diagnosis
How It is Monitored
Both procedures are performed under continuous ultrasound guidance. After the procedure, a short period of rest is recommended. Results for rapid testing (FISH or QF-PCR) are usually available within 2–3 days, with full karyotype results in 2–3 weeks. Microarray or specific gene testing may take longer.
How is Amniocentesis & CVS diagnosed?
These are diagnostic procedures performed when screening tests indicate elevated risk, when ultrasound findings suggest a chromosomal condition, or when specific genetic testing is needed. CVS is offered from 11 weeks; amniocentesis from 15 weeks.
How Dr. Kartik manages Amniocentesis & CVS
Dr. Kartik performs both procedures under continuous ultrasound guidance at Columbia Asia Hospital Bukit Jalil, with thorough pre-procedure counselling and clear explanation of results once available.
Why See an MFM Specialist?
MFM specialists are trained and experienced in performing these delicate procedures, minimising risk through precise ultrasound guidance. They also provide pre-procedure counselling to help families understand the risks, benefits, and implications of the results.
Dr. Kartik Balaraman Manages This Condition
Dr. Kartik performs amniocentesis and CVS with ultrasound guidance at Columbia Asia Bukit Jalil. If you have been advised to consider diagnostic testing, speak with Dr. Kartik about your options.
For personalised treatment of Amniocentesis & CVS at Columbia Asia Hospital Bukit Jalil, message Dr. Kartik directly on WhatsApp — no referral required.
Book ConsultationFrequently Asked Questions
Is amniocentesis painful?
Most women describe it as uncomfortable rather than painful — similar to a blood test. Local anaesthesia is used, and the procedure takes only a few minutes under ultrasound guidance.
What is the difference between CVS and amniocentesis?
CVS is performed earlier (11–14 weeks) and samples placental tissue. Amniocentesis is performed later (from 15 weeks) and samples amniotic fluid. Both provide definitive chromosomal results.
How long do results take?
Rapid results (for major chromosomal conditions) are typically available within 2–3 working days. Full results may take 2–3 weeks.
What are the alternatives to invasive testing?
Non-invasive prenatal testing (NIPT) screens for common chromosomal conditions with high accuracy from a simple blood test. For specific genetic conditions, diagnostic procedures remain the definitive option.
Will I feel the baby during the procedure?
The procedure is performed under continuous ultrasound guidance, so the baby is constantly monitored. You may feel pressure or a brief cramp, but most women tolerate the procedure well.
Related Conditions
Chromosomal & Genetic Screening
Screening and diagnostic tests to assess the risk of chromosomal conditions such as Down syndrome.
Fetal Structural Anomalies
When a detailed scan identifies a structural difference in the baby's development.
Detailed Anomaly Scans
A comprehensive ultrasound examination at 18–22 weeks to check the baby's structural development in detail.
Reviewed by Dr. Kartik Balaraman, Consultant OBGYN & Maternal Fetal Medicine Sub-Specialist ·
This page is for general education and does not replace personalised medical advice. If you have concerns about your pregnancy or health, consult a qualified specialist directly.